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Among the immediate-early response genes, expression of c-Jun and c-Fos is induced to form the transcription factor AP-1 that regulates transcription of genes implicated in cell proliferation or differentiation

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Advanced therapies should be chosen thoughtfully, ideally with clinician guidance, especially when they require higher investment

The combined effect of these drugs was similar in both the IGHV-mutated and unmutated CLL subsets