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We utilized Students t-tests and Pearson correlations for parameter comparisons

Western blotting Total protein was extracted from paraformaldehyde-fixed, paraffin-embedded pancreatic tissues using the FFPE Total Protein Extraction Kit (Sangon Biotech, Shanghai, China) or from cultured PSCs using RIPA Lysis Buffer (Beyotime)

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A gene's expression profile was considered associated with Lm if model 2 fit better than model 1 as determined by a significant P -value from a likelihood ratio test between the two models after applying a false discovery rate (FDR) correction