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Additionally, clinical studies are also required to understand whether there is correlation of serum or synovial fluid butyrate levels with ferroptosis markers (e.g., GPX4, ROS) or disease severity in OA patients, and the chondroprotective efficacy of butyrate supply to beneficial bacteria by probiotics or dietary fibers

use of laxative medications or other products that promote colon cleansing in the previous 4 weeks

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