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In certain instances, once drug exposure (e.g., concentration in the endolymph or perilymph) of a drug reaches steady state, the concentration of the drug in the endolymph or perilymph stays at or about the therapeutic dose for an extended period of time (e.g., one day, 2 days, 3 days, 4 days, 5 days, 6 days, 1 week, 2 weeks, 3 weeks, a month, two months, three months, six months, or one year)

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Apply the contents of the ampoule in a gel prepared for use in needle-free mesotherapy or virtual mesotherapy, or to enhance the results obtained with electrotherapy techniques such as ultrasound, ionization, diatherapy or other types of medical device used in beauty treatments

Specific inhibition of hypoxia inducible factor 1 exaggerates cell injury induced by in vitro ischemia through deteriorating cellular redox environment