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This is the direct mechanism by which MOTS-c improves insulin sensitivity

Cells were subsequently washed three times with PBS, fixed with 4% (w/v) formaldehyde for 30 min, washed again, and mounted on 1% (w/v) agarose pads for imaging by confocal microscopy

doi: 10.1016/j.freeradbiomed.2018.06.010 62 RobertsCKSindhuKK

Significant accumulation of lipid peroxides is observed in brain regions enriched with A oligomers and in 4-HNE-positive areas of AD patients, indicating direct involvement of A in the ferroptosis pathway (118)