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The approach must be individualized, balancing the need for brain folate restoration with methylation support, immune modulation, and gut healing to ensure the best possible outcome

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As an illustration, Figure 2A shows the fibrillar aggregates formed by the C-terminal fragment of TDP-43, called TDP-35 (Shenoy et al., 2019), associated with amyotrophic lateral sclerosis (Neumann et al., 2006)

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