Pharmaceutics 9(2):12 Cabrales P, Han G, Roche C, Nacharaju P, Friedman AJ, Friedman JM (2010) Sustained release nitric oxide from long-lived circulating nanoparticles
In animal experiments, the histopathology of the kidney of mice injected with a single dose of anti-VEGF antibody has shown glomerular endothelial cell swelling, vacuolization, detachment, and the rupture of the epithelial septum, while immunohistochemistry has also demonstrated that renin is down-regulated, and that the nephron could be partially restored with recombinant VEGF (68)
LC-MS/MS acquisitions For the discovery cohort, untargeted analysis samples were analyzed by nanoLC/MSMS using a Dionex UltiMate 3000 nanoRSLC liquid chromatography system (Thermo Fisher Scientific) interfaced to an Orbitrap Fusion Tribrid mass spectrometer (Thermo Fisher Scientific, San Jose, CA,USA) equipped with a nanoelectrospray ion source
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