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This dual mechanism is what separates it from earlier GLP-1 receptor agonists like semaglutide, and it is largely responsible for the compound superior efficacy data

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However, this ratio demonstrated a discriminative ability comparable to those of the individual metabolites, with AUC (95% CI) values of 0.73 (0.570.89), 0.70 (0.540.86), and 0.75 (0.600.91) for aKG, creatine, and their ratio, respectively (Fig