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Results indicate that DSIP-CBBBP effectively modulates neurotransmitter levels, particularly 5-HT, glutamate, dopamine, and melatonin, leading to improved sleep quality compared to DSIP alone

It is not established whether enough peptide survives first-pass absorption to produce meaningful systemic plasma concentrations for non-gastrointestinal targets

From this perspective, could epigenetics serve as a bridge between sustained antidepressant efficacy and neurexins that modulate synaptic plasticity