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Their dysfunction leads to increased oxidative stress and ROS production due to exhaustion of cellular antioxidative capacity [43,44,45]

MorganPESturgessADDaviesMJ.Evidence for chronically elevated serum protein oxidation in systemic lupus erythematosus patients

A randomized controlled trial of metformin on left ventricular hypertrophy in patients with coronary artery disease without diabetes: the MET-REMODEL trial