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Research in humans is a bit less impressive Clinical trials in humans A 1981 double-blind study found that chronic insomniac patients found that subjects slept 59% more, shorter sleep latency, and higher sleep efficiency (Schneider 1981) A 1987 double-blind study did not find any statistically significant changes in sleep structure as measured by REM sleep, NREM sleep, or total sleep time (Debellis 1987) A 1992 double-blind study in 14 chronic insomnia patients found higher sleep efficiency and subjectively estimated tiredness decreased to similar levels of healthy subjects in 7 nights of injections (Schneider 1992) There are some limitations to these studies however

Helps regulate the production of cytokines, the signaling molecules that drive inflammation

Song Q, Liao W, Chen X, He Z, Li D, Li B et al (2021) Oxalate activates autophagy to induce ferroptosis of renal tubular epithelial cells and participates in the formation of kidney stones

The perimenopausal years occur after the reproductive years, but before menopause