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This complex symptomatology reflects the widespread and multisystem nature of PD pathology, which extends far beyond the basal ganglia to involve cortical, limbic, and peripheral autonomic structures [3, 4]

Characteristically, Tyr possesses a hydrophilic nature attributed to its side chain, which features a hydroxyl group attached to a hydrophobic aromatic benzene ring (Ahsan 2013)

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Historical Background and Scientific Context Scientific interest in regulatory peptides increased significantly during the late twentieth century as molecular biology techniques advanced and researchers began mapping peptide signalling networks