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Suboptimal or deficient glutathione levels contribute to symptoms and disease risk

Prior study has also identified N-acetyl cysteine ethyl ester (NACET), an esterified and lipophilic NAC prodrug, as a promising alternative for reducing intracellular ROS [22, 23]

Effective treatment begins with early nonpharmacologic measures such as physiotherapy, occupational therapy, and psychological support, followed by cautious introduction of pharmacologic options such as gabapentinoids, SNRIs, TCAs, and NAC based on patient response and tolerance level

For all other instruments, 5% of the assessments will be double scored