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Altered PTEN pathway expression has been found to enhance the efficacy of anti-PD-1 and anti-CTLA-4 antibodies in mouse models 60 and to improve the chemoresistance of breast cancer cells to DOX 61

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DM-KG mouse model Female C57BL/6 J mice were purchased from Shanghai Lingchang Biotechnology Co., Ltd (Shanghai, China) and randomly assigned to two experimental groups based on body weight