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doi: 10.1073/pnas.1804764115 Guo, Shaodong, Herzig, Volker and King, Glenn F

Formulations typically feature tretinoin (0.050.1%) combined with vitamin C (1020%) and hyaluronic acid in a cosmetically elegant base

Importantly, de novo ser/gly synthesis pathway activation in lung cancer cells leads to increased GSH synthesis and folate-dependent NADPH production to regulate redox homeostasis, and enhanced purine synthesis to sustain proliferation [16,17,18]

Its clinical development was halted, so there is no completed pivotal trial, no approved label, no reviewed dose, and no regulatory safety determination