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Nature 412 , 549553 (2001)

Before azathioprine and 6-MP are administered, test all patients for TPMT and NUDT15 activity Patients with normal TPMT and NUDT15 activity may be treated with full-dose azathioprine or 6-MP Methotrexate Parenteral methotrexate at a dose of 25 mg weekly is effective for inducing and maintaining remission in patients with CD

1,11,19 Novel pharmacological agents, including sodium-glucose cotransporter 2 (SGLT2) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, and ion channel blockers, have shown promising neuroprotective and pain management effects

Therefore, appropriate management of gout with early intervention is critical, including adequate control of hyperuricemia and ultimate, permanent resolution of tophi with lifelong maintenance of a normal serum urate