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Treatment was also associated with reductions in body weight, high-sensitivity C-reactive protein level, systolic blood pressure and improvements in sleep-associated patient-reported outcomes

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The recent identification of hybrid ketoacid dehydrogenase complexes between the E1 subunit of OADHc (DHTKD1) and the OGDHc 40 indicates that more complex crosstalk exists between ketoacid dehydrogenases, and we speculate that these hybrid complexes may be more susceptible to acyl-lipoyl adduct formation