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[119] Writing for Variety , Todd McCarthy commended Winslet for "suppl[ying] a haunting shell to this internally decimated woman," and Sukhdev Sandhu of The Daily Telegraph considered her to be "absolutely fearless here, not just in her willingness to expose herself physically, but her refusal to expose her character psychologically." [120] [121] Winslet received significant awards attention for her performances in Revolutionary Road and The Reader

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The mRNA and protein levels of both mtTFA and cytochrome c oxidase subunit II (COX II) were significantly decreased, but the group of mice treated with 5-aza-2-deoxycytidine (AZA, a DNA methyltransferase inhibitor) had restoration of the above changes which suggesting that the removal of DNA methylation by AZA can protect against CSE-induced cell apoptosis

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