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Data Availability The data analyzed in this study are included in this published article and accompanying supplementary information files

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Under normal circumstances, beneficial bacteriaparticularly Lactobacillus specieskeep Candida populations in check

The reduction of roGFP2(S 2 ) is therefore a good example for an enzyme using an alternative reaction pathway to overcome a kinetic challenge, and we hypothesize that other non-glutathione disulfide substrates with reactive proximal cysteinyl residues and rather negative redox potentials also require a ternary complex for their reduction