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Probably the most important Hp virulence factor with a well established role in the induction of mucosal inflammation is cag (cytotoxin-associated gene) in the pathogenicity island ( cag PAI )

These systems also support the transplantation of human peripheral blood mononuclear cells, macrophages, neutrophils, or iPSC-derived immune cells into immunocompromised or early embryonic zebrafish, facilitating the construction of inflammation models with a humanized immune background

243 In skeletal muscle, HDAC1/2 maintain autophagic flux under stress conditions