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The rationale for titrating upward over time, rather than starting at the target dose, mirrors the approach taken with other metabolic peptides: the goal is to identify the minimum effective dose for each individual while monitoring for tolerability

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The Achilles Tendon Transection Model Foundational Evidence The Sikiric laboratorys Achilles tendon transection research established the foundational tissue-repair evidence base for BPC-157

SURMOUNT-MAINTAIN (Horn 2026, 112 weeks): continued top dose -21.9% vs 5 mg step-down -16.6% vs placebo -9.9%, rescue therapy 8/25/67%: Aronne JAMA 2024