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Additionally, dysfunctional Nrf2 cannot effectively regulate immune responses, leading to the excessive release of inflammatory factors, which worsens joint inflammation and damage

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Statins inhibit the HMGCR (rate-limiting enzyme) activity in early stages of mevalonate pathway and then indirectly affect a number of intermediate products, including non-sterol isoprenoids (coenzyme Q10, dolichol etc.), which can result in impaired functions of body organs