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These include vitamin B12 deficiency and malabsorption that is caused by the following medical conditions, according to the NIH [1]: Pernicious anemia Tropical sprue Pancreatic insufficiency Surgery in the gastrointestinal tract Certain medications Deficiency in the diet Side effects of B-12 injections Also, according to the NIH, vitamin B-12 injections have some potential side effects, including [1]: Diarrhea Itching Swelling Risk of allergic reaction and anaphylaxis Can Vitamins Aid in Weight Loss

Appetite-neutral mechanism Unlike incretin compounds, AOD-9604 acts on fat tissue rather than appetite centres, so animal models did not show the food-intake suppression seen with GLP-1 agonists [1]

It's particularly warranted if mood symptoms are accompanied by neurological signs (numbness, tingling, balance issues) or anemia symptoms (fatigue, pallor, shortness of breath)