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*Correspondence: Ricardo Tavares Pinheiro, [email protected] This article was submitted to Mood Disorders, a section of the journal Frontiers in Psychiatry Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Inhibition of the Xc- transport system and depletion of cystine The Xc- transport system, which is composed of SLC7A11 and SLC3A2 proteins imports cystine into the cell while exporting glutamate

As there is less variation in the production and breakdown of cystatin C compared to creatinine across populations, and because it is less influenced by body composition, cystatin C is considered a more accurate marker of kidney function