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As representative molecular chaperones, HSPs can regulate conformational changes by promoting correct protein folding and refolding, repair denatured proteins, prevent misfolding, and maintain cellular homeostasis, thus protecting the host [14]
Even though vitiligo is the most direct example, other autoimmune disorders, especially those affecting the thyroid, can disrupt the hormonal signals that regulate melanin production and speed up the appearance of the first gray hairs
Thus, DSePA, while radio-sensitizing lung cancer cells, prevents radiation-induced chronic inflammatory response in the normal lung parenchyma