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The development of cancer lesions can be in two different regions of the prostate gland, in the peripheral zone, which is most common, and the remaining lesions are found in the transition zone located in the periurethral region (McNeal, 1988)

One of its primary roles is to neutralize free radicalsunstable molecules that can cause cellular damage and contribute to inflammation

Notably, the effects of the high-dose group were comparable to those of the estradiol group [60]

A method for preventing drug-induced ototoxicity in an individual in need thereof comprising intratympanic administration of a pharmaceutical composition comprising a therapeutic agent selected from a JNK inhibitor, a TRPV modulator, an MET channel inhibitor, and an otoprotectant to the individual in need thereof, wherein the pharmaceutical composition is administered prior to onset of therapy with the drug, and wherein the composition provides sustained release of the therapeutic agent into the ear for a period of at least 5 days after a single administration