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Airway remodeling and the immune response in asthma pathogenesis have been associated with mitochondrial metabolism, including the redox state (84)

Methods Overall study design This open-label, randomised, crossover, clinical study received favourable opinion (equivalent to ethics approval) from the Office for Research Ethics Committees Northern Ireland (ORECNI) Health and Social Care Research Ethics Committee A (reference number 21/NI/0144) prior to study commencement

Interim sacrfices occurred at 6, 12, and 18 months