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the one or more hepatocyte growth factor mimics has or have a general structural formula R r R 2 -R 3 -NH-(CH 2 ) n -C-NH 2 Rj is one of an N-acyl group, a substituted or unsubstituted phenyl, a norleucine group, and an amino acid selected from tyrosine, phenylalanine, aspartic acid, arginine, isoleucine, serine, histidine, glycine, cysteine, methionine, tryptophan, lysine norvaline, ornithine, and s-benzyl cysteine

In general, the oral route has the lowest bioavailability of any route of administration

Both peptides influence extracellular matrix organization, a critical component of cartilage and synovial tissue maintenance

Potential benefits observed in research include: Animal models have shown significant decreases in disease severity with KPV treatment