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This functional disorder not only disrupts the normal regulatory mechanisms of blood vessels but also leads to increased blood pressure, arterial stiffness, and remodeling of small arteries, ultimately resulting in multi-organ damage (Boutouyrie et al., 2021

More serious side effects may include: Pancreatitis (inflammation of the pancreas) Gallbladder problems Kidney problems/failure Serious allergic reactions Increased heart rate Depression

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ME/CFS lacks standardised diagnostic criteria owing to variations in both inclusion and exclusion criteria across different diagnostic guidelines, and furthermore, there are currently no effective treatments available