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Use of ketamine for anesthesia has been associated with self-limited mild enzyme elevations, but not with clinically apparent liver injury, although chronic or intermittent use has been associated with biliary dilation and irregulaties

minimize oxygen and headspace

Aberrantly activated glial cells exacerbate neuroinflammation and influence synaptic pruning processes, with complement C4-mediated synaptic phagocytosis playing a critical role