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A New York Times article in 1901 warned that womens smoking of cigarettes was growing to be a menace in this country. In 1904, a police officer stopped a car on Fifth Avenue because one of the passengers, a woman, was smoking inside

The generated smoke/aerosol was exposed to temperatures ranging from 20 to 350 C, before sampling, to study how the organic matter evolved at different temperatures and to facilitate the analysis of possible residual solid particles

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Yet, the translation of these associations into mechanistic understanding remains hindered by methodological variability, inter-individual heterogeneity, and the intrinsic complexity of hostmicrobeenvironment interactions