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In preclinical research environments, BPC-157 has been evaluated for its interaction with signaling systems associated with endothelial function, cytoprotective mechanisms, inflammatory modulation, and cellular stress response pathways

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Gozes group has found that ADNP mutations affect MT dynamics and inhibit its interactions with Tau [348, 349], producing a tauopathy-like phenotype manifested in increased GSK-3 activity, Tau hyper-phosphorylation, and cognitive deficiency [293]