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Robuuste Phase 2/3-studies ontbreken vooralsnog en het grootste deel van het bewijs blijft preklinisch

10.1371/journal.pone.0129301 PLoS One 48 ThomasM.CraikJ

Abstract Background Cobalamin (cbl)-related remethylation disorders are a heterogeneous group of inherited disorders comprising the remethylation of homocysteine to methionine and affecting multiple organ systems, most prominently the nervous system and the bone marrow