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Several research studies have shown that oxidative stress is involved in the misfolding and accumulation of mutant huntingtin protein, which induces proteotoxicity and impairs oxidative metabolism, leading to neuronal damage and death 39 , 40

Single-dose pharmacokinetic parameters (maximum observed plasma concentration [ C max ], time to maximum plasma concentration [ T max ], area under the concentrationtime curve to the last observation [AUC (0 T ) ], area under the concentrationtime curve to infinity [AUC (INF) ], terminal half-life [ T 1/2 ], and renal clearance [CLR]) were derived from plasma concentration versus time and urinary excretion data

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These interactions have implications for pharmacokinetic distribution aspects