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Other peripheral biomarkers include circulating proteasome activity in plasma, which was significantly lower in patients with chronic tinnitus and mild cognitive impairment, suggesting a link to cognitive comorbidity (Yun et al., 2020), and hair cortisol and BDNF levels, where hair cortisol is positively correlated with perceived tinnitus loudness, and hair BDNF is negatively correlated with both perceived tinnitus loudness and tinnitus-related distress (Basso et al., 2022)
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