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They reduce mitochondrial oxidative damage by restricting mitochondrial ROS generation and increasing mitochondrial antioxidant systems such as mitochondrial SOD

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Oral semaglutide Oral semaglutide in doses up to 14 mg once daily gained approval as T2D treatment by the Food and Drug Administration (FDA) in September 2019 based on the results of the phase 3 trials of the PIONEER program (up to 1.4% HbA1c reduction and up to 4.4 kg WL in the global trials) and become the first approved oral GLP-1 RA [26]