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ZYBAN should be used with caution in patients with renal impairment and a reduced frequency and/or dose should be considered [see Use in Specific Populations (8.6)]

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These symptoms can include some or all of the following: Ear pain Clicking or popping sound when moving the jaw Muffled hearing (reduced hearing) Tinnitus (ringing) Swelling on the affected area of the mouth or face Lock jaw or jaw may not fully open Oftentimes, TMJ is accompanied with other symptoms such as, dizziness, headache, difficulty chewing and swallowing, jaw pain, facial pain, neck and shoulder stiffness

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