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Young JM et al (2001): Mecamylamine: new therapeutic uses and toxicity/risk profile

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The molecular mechanisms by which NaDOC alters the protein expression of molecules involved in the intestinal Ca 2+ absorption seem to be also related to nitrosative stress, as indicated by increment in NO content and in induced nitric oxide synthase (iNOS) protein expression, and apoptosis, as shown by enhancement of the system FASL/FAS/caspase-8/caspase-3

The results of that study showed that p38MAPK and PKC6 were not involved in HO-1 induction by curcumin, whereas the Protandim-mediated increase in HO-1 expression decreased by 50% in the presence of SB203580, an inhibitor of p38MAPK, and rottlerin, an inhibitor of PKG5