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The proposed mechanism described in papers that were later retracted is that it potentiates hepatocyte growth factor (HGF) signaling at the c-Met receptor, driving dendritic spine formation and synaptogenesis

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Effects of p21Cip1/Waf1 at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication