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According to clinical research parenteral administration (intramuscular or intravenous) is preferred over other drug administration routes in case of emergency situations as it provides first-pass metabolism avoidance, reliable therapeutic concentrations and better bioavailability of dosage (2) It can also be used in situations when oral route is not feasible

Roughly half of a dose of amphetamine undergoes oxidation to metabolites by hepatic P-450 metabolism (2D6), while the remainder is cleared by the kidney

1 US estimates of ME/CFS prevalence averaged 1 to 2.5 million before the COVID-19 pandemic

H., & Xu, Y