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A randomized trial published in the European Journal of Pain found that vitamin B12 significantly improved pain scores in patients with chronic low back pain compared to placebo

However, absence of evidence is not evidence of absence. The sample sizes were small, and rare side effects (or ones that occur with prolonged use) could easily have been missed

There was, however, a noticeable spike in motivation in the B12 group

Your provider can customize your dose beyond the standard steps The goal is the lowest dose that provides steady weight loss with fewest side effects Higher dose guideline of up to 7.2 mg weekly has been approved in the U.S