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Zhou, Y., et al., Disease burden of liver cancer in China from 1997 to 2016: an observational study based on the Global Burden of Diseases

BMJ 2 , 1662 (1960)

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Contraindications and precautions Consider avoiding DSIP or consulting a physician if: Pregnant or breastfeeding (insufficient safety data) Taking naloxone or other opioid antagonists (may block effects) Using medications metabolized by peptidases (potential interactions) History of immune disorders (theoretical immunogenicity concern) Already using multiple sleep medications Drug interactions Because DSIP degrades via amino-peptidases in blood, medications affecting these enzymes (like the ACE inhibitor captopril) could theoretically alter DSIP metabolism