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This pathway plays a critical role in tissue development and homeostasis, and its dysregulation has been widely implicated in tumorigenesis by promoting epithelial-mesenchymal transition (EMT), angiogenesis, cell proliferation, invasion, metastasis, and the maintenance of cancer stem cell-like properties 33,35,36,37,38,39

Recovery is a period of accelerated cellular work, and that work is bottlenecked when NAD+ availability is low