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Fresh tissue damage still has the cellular machinery for repair actively engaged, while chronic injuries may have entered a degenerative plateau

While topical products may be adequate for mild surface-level concerns, addressing established skin laxity with significant collagen and elastin loss typically requires the higher tissue concentrations achievable through injection

Interestingly, TNF-alpha has been shown to interrupt tight junctions, thus worsening any underlying tight junction dysfunction

The GLP-1 receptor, already operating at a structural disadvantage (higher EC50), may fall below the threshold for clinically significant activation