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Dihexa (PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a synthetic angiotensin IV analogue designed as a potent activator of neurotrophic signalling

Plasma GHK levels decline with age (from ~200 ng/mL in young adults to ~80 ng/mL by age 60), making it a heavily studied compound in dermal biology, fibroblast research, and tissue remodeling literature

Multiple other molecules (including combinations of entero-pancreatic hormones and oral GLP-1 RA) are in late phase clinical trials as potential obesity treatments, leading to WL that approaches the efficacy of bariatric surgery [101]

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