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Description

While NAPQI is normally detoxified by glutathione, in APAP overdose, glutathione is depleted and NAPQI binds to cysteine on hepatic proteins as 3-(cystein- S -yl) APAP

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Evidence suggests that iron regulates ECM deposition and remodeling via oxidative stress, indicating its critical role in ECM integrity (Maldonado and Nam, 2013