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Aerobic exercise, weight training, and fluid-loading protocols, such as the use of compression garments that pull blood back into the lower limbs through pressure differences, address cardiac deconditioning to help ease cardiovascular tolerance upon return to Earth 4,11,12,13

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This overlap suggests that FOXO4s activation by oxidative stress and inflammation might follow similar mechanisms, pointing to a broader role of FOXO4 in stress and immune response contexts