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Mental and Cognitive Health Advantages Regular sauna use reduces the risks of dementia, Alzheimers disease, and cognitive decline by promoting cerebral blood flow and increasing production of brain-derived neurotrophic factor (BDNF), a molecule essential for brain health and neuroplasticity

It may promote abnormal angiogenesis (new blood-vessel growth), raising theoretical concerns in patients with cancer history

Oxford University Press

Therefore, by activating this NCOA4-mediated ferritinophagy pathway, Erastin promotes the release of free iron, which in turn amplifies ROS production and lipid peroxidation, resulting in an autophagy-dependent mode of ferroptosis