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The main reason titanium dioxide was used to treat skin cancer was that it produces reactive oxygen species (ROS) when exposed to light or UV radiation, however, it lacks selectivity and also damages nearby healthy cells

Association between fish oil supplementation and cancer risk according to fatty fish consumption: a large prospective population-based cohort study using UK Biobank

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Similarly, peripheral inflammation originating in the gut and spreading through the bloodstream has been identified as a potential risk factor for AD, correlating with elevated amyloid levels in AD dementia [100, 101]