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Besides, the effects of berberine in Alzheimers mice may be related to the inhibition of NF-B activity and lipid peroxidation, and the increase of glutathione activity in the hippocampus (He et al., 2017) (Figure 2)

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Similarly, negative studies are less likely to be published, so our data are likely to reflect this publication bias in favor of positive research, particularly in the years prior to the requirement for clinical trial registration [63, 64]